The Role of Mitochondrial Biogenesis in Ischemic Stroke

Ischaemic stroke is a sudden neurological disorder caused by localised cerebral ischaemia and persistent infarction. Occlusion of large arteries due to atherothrombosis, embolism (i.e., embolic infarction), no thrombotic occlusion in small, deep lacunar stenosis proximal hypotension leading decreased blood flow arterial supply zones are the most common causes ischemic hemodynamic stroke). It now known that organelles play an important role various signaling events cellular functions. The molecular mechanisms mitochondria involved ischemia generating scavenging reactive oxygen species, apoptosis, biogenesis, mitochondrial dynamics, inflammation all examples electron transport chain dysfunction. More knowledge about involvement ischemia-induced neuronal death protection will contribute development better treatment programs for syndromes such as stroke.